Carbohydrate PEGylation, an approach to improve pharmacological potency

Carbohydrate PEGylation, an approach to improve pharmacological potency

Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully...

An approach to Improve Particle Swarm Optimization Algorithm Using CUDA

The time consumption in solving computationally heavy problems has always been a concern for computer programmers. Due to simplicity of its implementation, the PSO (Particle Swarm Optimization) is a suitable meta-heuristic algorithm for solving computationally heavy problems. However, despite the simplicity, the algorithm is inefficient for solving real computationally heavy problems but the pr...

Pharmacological Approaches to Improve Ageing

PEGylation of Concanavalin A to Improve Its Stability for an In Vivo Glucose Sensing Assay

Competitive binding assays utilizing concanavalin A (ConA) have the potential to be the basis of improved continuous glucose monitoring devices. However, the efficacy and lifetime of these assays have been limited, in part, by ConA's instability due to its thermal denaturation in the physiological environment (37 °C, pH 7.4, 0.15 M NaCl) and its electrostatic interaction with charged molecules ...

non-corrective approach to pronunciation

the aim of this study has been to find answers for the following questions: 1. what is the effect of immediate correction on students pronunciation errors? 2. what would be the effect of teaching the more rgular patterns of english pronunciation? 3. is there any significant difference between the two methods of dealing with pronuciation errore, i. e., correction and the teaching of the regular ...